Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

• Makoto Komiyama

Beilstein J. Nanotechnol. 2023, 14, 218–232, doi:10.3762/bjnano.14.21

• . Alternatively, therapeutic nucleic acids are stably protected in the nanoarchitectures and delivered to the target site. The efficient delivery of the CRISPR-Cas9 system for gene editing was also successful. Even more complicated nanoarchitectures can be designed for sophisticated DDSs. Cyclodextrin-based

• chromophores, induced by photoirradiation, ultimately decompose the whole nanoarchitecture for drug release. In section 3, various therapeutic nucleic acids are delivered to the target site by CyD nanoarchitectures. By embracing with chemically modified CyDs, otherwise fragile nucleic acids are successfully

• upconversion nanoparticles, which in turn cleaved the covalent linkages between pyrene molecules and the mesoporous silica layer. As the result, the pores were unblocked and the encapsulated drugs were released. 3 CyD-based nanoarchitectures to deliver therapeutic nucleic acids to the target site Therapeutic

Long-term stability and scale-up of noncovalently bound gold nanoparticle-siRNA suspensions

• Anna V. Epanchintseva,
• Julia E. Poletaeva,
• Dmitrii V. Pyshnyi,
• Elena I. Ryabchikova and
• Inna A. Pyshnaya

Beilstein J. Nanotechnol. 2019, 10, 2568–2578, doi:10.3762/bjnano.10.248

• nanoparticles (AuNPs) are a platform for the creation of nanoconstructions that can have a variety of functions, including the delivery of therapeutic nucleic acids. We previously designed a AuNP/small interfering RNA (siRNA) nanoconstruction consisting of siRNA noncovalently bound on the AuNP surface and

• of physicochemical characteristics and siRNA surface density for a long period. Keywords: colloidal stability; gold nanoparticles; scale-up; siRNA delivery; siRNA duplex stability; therapeutic nucleic acids; Introduction Drug delivery to cells is only one application of nanoparticles in biomedicine

• ; however, it occupies an important place in scientific research. The delivery of therapeutic nucleic acids (TNAs) is of particular importance due to their operation at the genomic level, and various nanoparticles (NPs) have been studied as carriers of TNAs (i.e., metallic, lipid, polymer, and peptide NPs

Non-agglomerated silicon–organic nanoparticles and their nanocomplexes with oligonucleotides: synthesis and properties

• Asya S. Levina,
• Marina N. Repkova,
• Nadezhda V. Shikina,
• Zinfer R. Ismagilov,
• Svetlana A. Yashnik,
• Dmitrii V. Semenov,
• Yulia I. Savinovskaya,
• Natalia A. Mazurkova,
• Inna A. Pyshnaya and
• Valentina F. Zarytova

Beilstein J. Nanotechnol. 2018, 9, 2516–2525, doi:10.3762/bjnano.9.234

• work was supported by the grant no. 16-15-10073 from the Russian Scientific Foundation. The study of the antiviral activity of the proposed nanocomplexes was supported partially under State funded budget project (VI.62.1.3, 0309-2016-0005) “Therapeutic nucleic acids”.